Adjunct Professor

Cannon Research Center

Email:

Education:

Professional Experience:

Research Interests:

• The combined transcriptome and proteome analysis of peripheral gene expression for early diagnosis and disease stage stratification in patients with amyotrophic lateral sclerosis (ALS)
• The development of in vitro cell culture models for ALS, based on stem cell-derived motor neurons.
• The role of TARDBP gene product TDP43 in ALS pathogenesis
• The determination of potassium channels as potential drug targets in ALS
• The application of systems biology tools to analyze complex biological data in various human diseases
• The alteration of gene expression in oral mucosa following cancer chemotherapy

Publications:

Mougeot, JL, Bahrani-Mougeot FK, Coleman S, Lockhart PB, and Brennan MT. (2010). Microarray analysis of oral biopsies of patients with chemotherapy-induced oral mucositis (submitted)

Napeñas JJ, Brennan MT, Coleman S, Kent, ML, Noll, J, Frenette G, Fox PC, Mougeot, J-L, Paster BJ,Lockhart PB, and Bahrani-Mougeot FK. (2010) Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: A pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109: 554-560

Mougeot, J.L., Milazi-Richardson, S. and Brooks, B.R. (2009). Whole-genome association studies of sporadic amyotrophic lateral sclerosis: are retroelements involved? Trends in Molecular Medicine. Vol 15 (4) pp. 148-158.

Mougeot, J.L., Bonkovsky, H.L., Brooks B.R. (2009). Genetic polymorphisms in ALS revisited: a systems biology approach. Amyotrophic Lateral Sclerosis. Vol 9 (Supl. 1) p97.

Hemendinger R.A., Armstrong III E.J., Persinski R., Todd J., Mougeot J.L., Panov A., Volvovitz F. and Rosenfeld J. (2008). Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. Neurotox. Res., 13: 49-62.

Gruber, H.E., Mougeot J. L., Hoelscher, G., Ingram, J. A. and Hanley, E.N. (2007). Microarray analysis of laser capture microdissected-annulus cells from the human intervertebral disc. Spine 32(11), pp 1181–1187.

Mougeot, J. L., Bahrani-Mostafavi, Vachris, J.C., McKinney, K.Q., Svetlana, G., R., Zhang, J., Naumann, R.W. Higgins R.V. and Hall, B.J. (2006). Gene expression profiling of ovarian tissues for determination of molecular pathways reflective of tumorigenesis. J. Mol. Biol. 358(1), 310-329.

Marshburn, P.B., Zhang, J., Bahrani-Mostafavi, Z., Mostafavi, B. Z., Mougeot J. L., Roshon, M., (2003). Estrogen receptor-alpha mRNA variants lacking exon 5 or exon 7 are co-expressed with wild type form during all stages of human endometrial development. Am. J. Obstetrics & Gynecology 191, 626-634.

Leclerc, D., Burri, L., Kajava, A.V., Mougeot, J. L., Hess, D., Lustig, A., Kleemann, G. and Hohn, T. (1998) The open reading frame III product of cauliflower mosaic virus forms a tetramer through a N-terminal coiled-coil. J. Biol. Chem. 273 (44), 29015-29021.

Piqué, M., Mougeot, J. L., Geldreich, A., Guidasci, T., Mesnard, J.M. and Yot, P. (1995) Sequence of a cauliflower mosaic virus strain infecting solanaceous plants. Gene 155, 305-306.

Mougeot, J. L. (1995) Etude du processus d’encapsidation du virus de la mosaïque du chou-fleur (CaMV). Publication of Université Louis Pasteur, Strasbourg.

Dautel, S., Guidasci, T., Mougeot, J. L., Lebeurier, G., Yot, P. and Mesnard, J.M. (1994) The full-length product of cauliflower mosaic virus open reading frame III is associated with the viral particle. Virology 202, 1043-1045.

Mesnard, J.M., Mougeot, J. L., Geldreich, A. and Lebeurier, G. (1993) Characterisation of different electrophoretic forms of cauliflower mosaic virus virions (strain Cabb-S). Biochimie 75, 645-649.

Mougeot, J. L., Guidasci, T., Wurch, T., Lebeurier, G. and Mesnard, J.M. (1993) Identification of C-terminal amino acid residues of cauliflower mosaic virus open reading frame III protein responsible for its DNA-binding activity. Proc.Natl.Acad.Sci. USA 90, 1470-1473.

Lebeurier, G., Guidasci, T., Henry, L., Mougeot, J. L., Wurch, T., Geldreich, A. and Mesnard, J.M. (1992) Virus movement and encapsidation/decapsidation of plant pararetrovirus: Cauliflower Mosaic Virus (CaMV). Mol.Biol. (Life Sci. Adv.) 11, 119-125.

Mougeot, J. L., Guidasci, T., Wurch, T., Geldreich, A, Mesnard, J.M., Jeltsch, J.M. and Lebeurier, G. (1992) Single amino acid change in the proline-rich motif of the minor capsid protein of cauliflower mosaic virus alters its interaction with the viral genome. Biotechnology and plant protection.

Mesnard, J.M., Guidasci, T., Mougeot, J. L. and Lebeurier, G. (1992) Etude de la maturation de polypeptides viraux chez un virus de plante: le virus de la mosaïque du chou-fleur. Interactions -Virus/Cellules, edition Société Française de Microbiologie, 111-119.

Guidasci, T., Mougeot, J. L., Lebeurier, G. and Mesnard, J.M. (1992) Etude in vitro de la maturation de la maturation du composant mineur de la capside du virus de la mosaïque du chou-fleur. Biochimie et Biologie Moléculaire.

Guidasci, T., Mougeot, J. L., Lebeurier, G. and Mesnard, J.M. (1992) Processing of the minor capsid protein of the cauliflower mosaic virus requires a cysteine proteinase. Research in Virology 143, 361-370.

Mesnard, J.M., Guidasci, T., Mougeot, J. L., and Lebeurier, G. (1991) Study of the maturation of cauliflower mosaic virus gene III product. Plant Sciences Today.