Adjunct Full Profosser

Cannon Research Center

Email:

Education:

Professional Experience:

• Director, Office of Research and Sponsored Programs (ORSP), University of Connecticut Health Center (Farmington, Conn.)
• Chairman, Institutional Review Board, New York City Department of Health & Mental Hygiene (New York, N.Y.)
• Clinical Associate Professor of Medicine, New York Medical College (Valhalla, N.Y.)
• Assistant Professor of Medicine, New York Medical College, (Valhalla, N.Y.)
• Director, Research Information and Development Office of Research Administration, New York Medical College (Valhalla, N.Y.)
• Director, Sepsis Immunology Laboratory, Department of Medicine Saint Vincent's Hospital and Medical Center
  of New York (New York, N.Y.)
• Research Manager, Department of Medicine, Saint Vincent's Hospital and Medical Center of New York (New York, N.Y.)

Research Interests:

Dr. Saha's research interests are in the area of sepsis and septic shock, especially in sepsis immunology. Currently, he is working to develop a drug for the prevention and cure of sepsis for which he as obtained a patent as well as another patent pending.Dr. Saha found that BisEDT (bismuth ethanidithiol) works as an immunomodulator in a mouse model of sepsis and septic shock and improves survival after septic shock has developed.

Publications:

Saha, D.C., C. Carpati, M.E. Astiz, E.C. Rackow (2009) Cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in a sepsis model. J. Amer. Assoc Lab. Anim. Sci. (submited).

Saha, D.C, A.C. Saha, G. Malik, M.E. Astiz, E.C. Rackow (2007) Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats. J. Amer. Assoc Lab. Anim. Sci. 46:74-80. [PMID: 17343357]

Barua, R.S., Ambrose, J.A., Saha, D.C., Eales-Reynolds, L-J (2002). Smoking is associated with altered endothelial-derived fibrinolytic and antithrombotic factors. An in vitro demonstration. Circulation. 106:905-908. [PMID: 12186791]

Barua, R.S., Ambose, J.A., Eales-Reynolds, L-J., De Voe, M.C., Zervas, J.G., Saha, D.C.in vivo and in vitro correlation. Amer. J. Cardiol. 39:1758-1763. [PMID 12039488] (2002). Heavy and light cigarette smokers have similar dysfunction of the endothelial vasoregulatory activity: An

Kirschenbaum, L.A., Adler, D., Astiz, M.D., Barua, R.S., Saha, D.C., Rackow, E.C. (2002). Mechanism of Platelet-neutrophil interactions and effects on cell filtration is septic shock. Shock. 17:502-510. [See Article]

Barua, R.S., Ambrose, J.A., Eales-Reynolds, L-J., De Voe, M.C., Zervas, J.G., Saha, D.C.[PMID: 11602492] (2001). Dysfunctional endothelial nitric oxide biosynthesis in health smokers with impaired endothelium-dependent vasodilatation. Circulation. 104:1905-1910.

Ambrose, J.A., Doss, R., Geagea, J-P., Hawkey, M.C., Duvuri, S., Giedd, K., Dominguez, A., Coppola, J., Nguyen, T.H., Palla, V., Barua, R.S., and Saha, D.C. (2001). Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. Amer. J. Cardiol. 87:1231-1233. [PMID: 11356410]

Saha, D.C., Barua, R.S., Astiz, M.E., Rackow, E.C., and Eales-Reynolds, L-J. (2001). Monophosphoryl lipid A stimulated up-regulation of reactive oxygen intermediates in human monocytes in vitro. Leukocyte Biol. 381-385. [PMID: 11527987]

Sfier, T., Saha, D.C., Astiz, M., Rackow, E.C. (2001). Role of interleukin-10 in monocyte hyporesponsiveness associated with septic shock. Crit. Care Med. 29:129-133. [PMID: 11176172]

Podel, J., Hodlein, R., Saha, D.C., Burns, G. (2000). Glucose absorption in acute peritoneal dialysis. Amer. J. Renal Nutr. 10:93-97. [PMID: 10757822]